Acamprosate
Campral
Tablet
- Modified-release
Acetaminophen
Tylenol Arthritis Pain
Extended-Release (US)
Tablet
- Modified-release
Albuterol
VoSpire ER (US)
Tablet
- Modified-release
Alendronate
Fosamax
Tablet
- Irritant (oropharyngeal)
Alfuzosin
Uroxatral (US),
Xatral (Canada)
Tablet
- Modified-release
Alprazolam
Xanax XR (US)
Tablet
- Modified-release
Ambrisentan
Letairis (US),
Volibris (Canada)
Tablet
- Teratogenic
Amoxicillin/Clavulanate
Augmentin XR (US)
Tablet
- Modified-release
- Scored tablets can be split
Apremilast
Otezla (US)
Tablet
- Antineoplastic
Aprepitant
Emend (US)
Capsule
- Nanocrystal
Aspirin
Ecotrin
Tablet
- Modified-release
- Irritant (gastric)
Aspirin/Dipyridamole
Aggrenox
Capsule
- Modified-release
- Can be opened for administration of intact granules
Atomoxetine
Strattera
Capsule
- Irritant (ocular)
Axitinib
Inlyta
Tablet
- Antineoplastic
Belladonna Alkaloids
Donnatal Extentabs (US)
Tablet
- Modified-release
Benzonatate
Tessalon Perles (US)
Capsule
- Local anesthetic effect could increase the risk of choking
Bisacodyl
Dulcolax
Capsule
Tablet
- Modified-release
- Irritant (gastric)
Bosutinib
Bosulif
Tablet
- Antineoplastic
Budesonide
Entocort EC (US),
Entocort (Canada)
Capsule
- Modified-release
- Can be opened for administration of intact granules
Budesonide
Uceris (US)
Tablet
- Modified-release
Buprenorphine
Belbuca(US)
Film
- Sublingual dosage form
Bupropion
Aplenzin (US),
Budeprion SR (US), Wellbutrin SR, XL,
Zyban
Tablet
- Modified-release
Cabozantinib
Cabometyx, Cometriq (US)
Capsule, Tablet
- Antineoplastic
Carbamazepine
Carbatrol (US),
Equetro (US)
Capsule
- Modified-release
- Can be opened for administration of intact granules
Carbamazepine
Tegretol XR (US),
Tegretol CR (Canada)
Tablet
- Modified-release
Carvedilol
Coreg CR (US)
Capsule
- Modified-release
- Can be opened for administration of intact granules
Cefuroxime
Ceftin
Tablet
- Bad taste
Chlorpheniramine Maleate
Chlor-Trimeton Allergy
12 Hour (US)
Tablet
- Modified-release
Ciprofloxacin
Cipro
Tablet
- Bad taste
Ciprofloxacin
Cipro XR (US),
Cipro XL (Canada)
Tablet
- Modified-release
Clarithromycin
Biaxin XL
Tablet
- Modified-release
Clonidine
Kapvay (US)
Tablet
- Modified-release
Colestipol
Colestid
Tablet
- Modified-release
Cyclobenzaprine
Amrix (US)
Capsule
- Modified-release
Cyclophosphamide
generics
Capsule
Tablet
- Antineoplastic
Dabigatran
Pradaxa
Capsule
- Intact product must be taken to avoid increased exposure
Dalfampridine
Ampyra (US)
Tablet
- Modified-release
Darifenacin
Enablex
Tablet
- Modified-release
Dasatinib
Sprycel
Tablet
- Antineoplastic
- Teratogenic
Deferasirox
Exjade
Tablet
- Tablet is for oral suspension
Desvenlafaxine
Pristiq
Tablet
- Modified-release
Dexlansoprazole
Dexilant
Capsule
- Modified-release
- Can be opened for administration of intact granules
Dexmethylphenidate
Focalin XR (US)
Capsule
- Modified-release
- Can be opened for administration of intact granules
Dextroamphetamine
Dexedrine
Capsule
- Modified-release
Dextroamphetamine/
Amphetamine
Adderall XR
Capsule
- Modified-release
- Can be opened for administration of intact granules
Diclofenac
Voltaren XR (US),
Voltaren SR (Canada)
Tablet
- Modified-release
Diclofenac/Misoprostol
Arthrotec
Tablet
- Modified-release
- Irritant (gastric)
- Teratogenic
Didanosine
Videx EC
Capsule
- Modified-release
Diflunisal
Generics
Tablet
- Irritant (gastric)
Diltiazem
Cardizem CD,
Cartia XT (US),
Dilacor XR (US),
Dilt-XR (US),
Taztia XT (US),
Tiazac
Capsule
- Modified-release
- Can be opened for administration of intact granules (Taztia XT and Tiazac)
Diltiazem
Cardizem
Cardizem LA (US),
Tiazac XC (Canada)
Tablet
- Modified-release
Dimethyl Fumarate
Tecfidera
Capsule
- Modified-release
Disopyramide
Norpace CR (US)
Capsule
- Modified-release
Divalproex
Depakote Sprinkle (US)
Capsule
- Modified-release
- Can be opened for administration of intact granules
Divalproex
Depakote (US),
Depakote ER (US),
Epival ECT (Canada)
Tablet
- Modified-release
Docusate Sodium
Colace
Capsule
- Bad taste
Donepezil
Aricept
(23 mg strength only)
Tablet
- Intact product must be taken to avoid increased rate of absorption
Doxazosin
Cardura XL (US)
Tablet
- Modified-release
Doxycycline
Doryx (US),
Apprilon (Canada)
Capsule, Tablet
- Modified-release
- Scored tablets can be split
Duloxetine
Cymbalta
Capsule
- Modified-release
Dutasteride
Avodart,
Jalyn
Capsule
- Teratogenic
- Irritant (mucous membrane)
Elbasvir/Grazoprevir
Zepatier (US)
Tablet
- Amorphous solid dispersion
Elexacaftor/Tezacaftor/
Ivacaftor
Trikafta
Tablet
- Amorphous solid dispersion
Enzalutamide
Xtandi
Capsule
- Antineoplastic
Ergotamine
Ergomar (US)
Tablet
- For sublingual administration
Erythromycin
Erythromycin
delayed-release
Capsule
- Modified-release
- Can be opened for administration of intact granules
Erythromycin
E.E.S.
Tablet
- Bad taste
Erythromycin
Ery-Tab (US),
PCE
Tablet
- Modified-release
Esomeprazole
Nexium
Capsule (US),
Tablet (Canada)
- Modified-release
- Capsule can be opened for administration of intact granules
Eszopiclone
Lunesta (US)
Tablet
- Bad taste
Etravirine
Intelence
Tablet
- Amorphous solid dispersion
- Tablet may be dispersed in water
- Scored tablets can be split
Everolimus
Afinitor
Zortress (US)
Tablet
- Amorphous solid dispersion
- Irritant (mucous membrane)
- Teratogenic
Felodipine
Plendil
Tablet
- Modified-release
Fenofibrate
TriCor (US)
Tablet
- Nanocrystal
Fentanyl
Abstral
Tablet
- Sublingual dosage form
Fentanyl
Actiq (US)
Lozenge
- Lozenge should be sucked, not chewed
Fentanyl
Fentora
Tablet
- Buccal dosage form
Ferrous Gluconate
Fergon (US)
Tablet
- Modified-release
- Irritant (gastric)
Ferrous Sulfate
Feosol (US),
Feratab (US)
Tablet
- Modified-release
- Irritant (gastric)
Fesoterodine
Toviaz
Tablet
- Modified-release
Fexofenadine/
Pseudoephedrine
Allegra-D
Tablet
- Modified-release
Finasteride
Propecia,
Proscar
Tablet
- Teratogenic
Fluoxetine
Prozac Weekly (US)
Capsule
- Modified-release
Fluvastatin
Lescol,
Lescol XL
Capsule, Tablet
- Modified-release (Lescol XL)
Fluvoxamine
Luvox CR (US)
Capsule
- Modified-release
Gabapentin
Gralise (US),
Horizant (US)
Tablet
- Modified-release
Galantamine
Razadyne ER (US),
Reminyl ER (Canada)
Capsule
- Modified-release
Glecaprevir/Pibrentasvir
Mavyret (US)
Tablet
- Amorphous solid dispersion
Glipizide
Glucotrol XL (US)
Tablet
- Modified-release
Guaifenesin
Mucinex (US)
Tablet
- Modified-release
Guaifenesin/
Dextromethorphan
Mucinex DM (US)
Tablet
- Modified-release
Guaifenesin/
Pseudoephedrine
Mucinex D (US)
Tablet
- Modified-release
- Scored tablets can be split
Guanfacine
Intuniv (US),
Intuniv XR (Canada)
Tablet
- Modified-release
Hydromorphone
Exalgo (US),
Jurnista (Canada)
Tablet
- Modified-release
Hydroxyurea
Droxia (US),
Hydrea
Capsule
- Irritant (cytotoxic)
Hyoscyamine
Levbid (US)
Capsule
Tablet
- Modified-release
- Scored tablets can be split
Ibandronate
Boniva (US)
Tablet
- Irritant (oropharyngeal)
Ibuprofen
Advil,
Motrin
Tablet
- Bad taste
Imatinib
Gleevec
Tablet
- Antineoplastic
- Irritant (mucous membrane)
- Scored tablets can be split
Indinavir
Crixivan
Capsule
- Bad taste
- Can be opened for administration of intact granules
Indomethacin
Indocin SR (US)
Capsule
- Modified-release
- Can be opened for administration of intact granules
Isavuconazonium Sulfate
Cresemba
Capsule
- High risk of instability or reduced absorption
Isosorbide Dinitrate
Dilatrate-SR (US)
Capsule
- Modified-release
Isosorbide Dinitrate
Isordil Sublingual (US)
Tablet
- Sublingual dosage form
Isosorbide Mononitrate
Imdur
Tablet
- Modified-release
- Scored tablets can be split
Isotretinoin
Absorica (US),
Accutane (Canada),
Amnesteem (US),
Clarus (Canada),
Epuris (Canada)
Capsule
- Irritant (esophageal)
- Teratogenic
Itraconazole
Sporanox
Capsule
- Amorphous solid dispersion
Ivacaftor
Kalydeco
Tablet
- Amorphous solid dispersion
Ivosidenib
Tibsovo (US)
Tablet
- Amorphous solid dispersion
Lamotrigine
Lamictal XR (US)
Tablet
- Modified-release
Lansoprazole
Prevacid
Capsule
- Modified-release
- Can be opened for administration of intact granules
Lansoprazole
Prevacid SoluTab (US),
Prevacid FasTab (Canada)
Tablet
- Should be dissolved in the mouth, not chewed
Lenalidomide
Revlimid
Capsule
- Teratogenic
Levetiracetam
Keppra
Tablet
- Bad taste
Levetiracetam
Keppra XR (US)
Tablet
- Modified-release
Levodopa/Carbidopa
Sinemet CR
Tablet
- Modified-release
- Scored tablets can be split
Levomilnacipran
Fetzima
Capsule
- Modified-release
Lithium Carbonate
Lithobid (US),
Lithmax (Canada)
Tablet
- Modified-release
Lopinavir/Ritonavir
Kaletra
Tablet
- Amorphous solid dispersion
- Reduced bioavailability with crushing8
Loratadine/
Pseudoephedrine
Claritin-D (US),
Claritin Allergy and Sinus (Canada)
Tablet
- Modified-release
Lovastatin
Altoprev (US)
Tablet
- Modified-release
Lubiprostone
Amitiza (US)
Capsule
- Stability is compromised
Lumacaftor/Ivacaftor
Orkambi
Tablet
- Amorphous solid dispersion
Memantine
Namenda XR
Capsule
- Modified-release
- Can be opened for administration of intact granules
Mesalamine
Asacol,
Lialda (US)
Pentasa
Capsule (US),
Tablet (Canada)
- Modified-release
- Capsules can be opened for administration of intact granules (Delzicol, Pentasa [US])
Mesalamine
Asacol,
Lialda (US)
Tablet
- Modified-release
Metformin
Fortamet (US),
Glucophage XR (US), Glumetza
Tablet
- Modified-release
Methylphenidate
Metadate CD (US),
Ritalin LA (US),
Biphentin (Canada)
Capsule
- Modified-release
- Can be opened for administration of intact granules
Methylphenidate
Concerta,
Metadate ER (US), Methylin ER (US),
Ritalin SR
Tablet
- Modified-release
Metoprolol Succinate
Toprol-XL (US)
Tablet
- Modified-release
- Scored tablets can be split
Metoprolol Tartrate
Lopressor SR (Canada)
Tablet
- Modified-release
Metronidazole
Flagyl ER (US)
Tablet
- Modified-release
Minocycline
Solodyn (US)
Tablet
- Modified-release
Mirabegron
Myrbetriq
Tablet
- Modified-release
Morphine Sulfate
Kadian
Capsule
- Modified-release
- Can be opened for administration of intact granules
Morphine Sulfate
MS Contin
Tablet
- Modified-release
Mycophenolate
CellCept
Capsule, Tablet
- Teratogenic
Mycophenolic Acid
Myfortic
Tablet
- Modified-release
- Teratogenic
Naproxen
EC Naprosyn (US), Naprelan
Tablet
- Modified-release
Nevirapine
Viramune XR
Tablet
- Modified-release
Niacin
Niaspan,
Niaspan FCT (Canada)
Tablet
- Modified-release
Nicardipine
Cardene SR (US)
Capsule
- Modified-release
Nicotine
Nicorette (US)
Lozenge
- Should be dissolved in the mouth, not chewed
Nifedipine
Adalat CC (US),
Procardia XL (US),
Adalat XL (Canada)
Tablet
- Modified-release
Nilotinib
Tasigna
Capsule
- Antineoplastic
- Modified-release
- Can be opened for administration of intact granules
Nisoldipine
Sular (US)
Tablet
- Modified-release
Nitroglycerin
Nitrostat
Tablet
- Sublingual dosage form
Olaparib
Lynparza
Tablet
- Amorphous solid dispersion
Omeprazole
Prilosec (US),
Prilosec OTC (US),
Losec (Canada)
Capsule, Tablet
- Modified-release
- Capsule can be opened for administration of intact granules (Prilosec)
Orphenadrine
Norflex ER (US)
Tablet
- Modified-release
Oxybutynin
Ditropan XL
Tablet
- Modified-release
Oxycodone
OxyContin (US),
Oxy Neo (Canada),
Xtampza ER (US)
Capsule, Tablet
- Modified-release
Oxymorphone
Opana ER (US)
Tablet
- Modified-release
Paliperidone
Invega
Tablet
- Modified-release
Pancreatic Enzymes
Creon,
Pancreaze (US),
Pertzye (US),
Zenpep (US)
Capsule
- Modified-release
- Irritant (oral mucosal)
- Can be opened for administration of intact granules
Pantoprazole
Protonix (US),
Pantoloc (Canada)
Tablet
- Modified-release
Paroxetine
Paxil CR
Tablet
- Modified-release
Pazopanib
Votrient
Tablet
- Antineoplastic
Pentoxifylline
Trental (US)
Tablet
- Modified-release
Piroxicam
Feldene (US)
Capsule
- Irritant (oropharyngeal)
Pomalidomide
Pomalyst
Capsule
- Antineoplastic
- Teratogenic
Posaconazole
Noxafil DR (US)
Posanol (Canada)
Tablet
- Amorphous oral dispersion
- Modified-release
Potassium Chloride
Micro-K (US)
Capsule
- Modified-release
- Can be opened for administration of intact granules
Potassium Chloride
Klor-Con (US)
Tablet
- Modified-release
Praziquantel
Biltricide
Tablet
- Bad taste
- Scored tablets can be split
Propafenone
Rythmol SR (US)
Capsule
- Modified-release
Propranolol
Inderal LA,
InnoPran XL (US)
Capsule
- Modified-release
Pseudoephedrine
Sudafed 12 Hour, 24 Hour (US)
Tablet
- Modified-release
Pseudoephedrine/
Brompheniramine
LoHist 12D (US)
Tablet
- Modified-release
Pseudoephedrine/
Desloratadine
Clarinex D (US)
Tablet
- Modified-release
Pseudoephedrine/
Fexofenadine
Allegra D
Tablet
- Modified-release
Pyridostigmine
Mestinon Timespan (US),
Mestinon SR (Canada)
Tablet
- Modified-release
Quetiapine
Seroquel XR
Tablet
- Modified-release
Rabeprazole
Aciphex (US),
Aciphex Sprinkle (US),
Pariet (Canada)
Capsule, Tablet
- Modified-release
Raloxifene
Evista
Tablet
- Bad taste
- Teratogenic
Ranolazine
Ranexa (US)
Tablet
- Modified-release
Regorafenib
Stivarga
Tablet
- Amorphous solid dispersion
- Antineoplastic
Risedronate
Actonel
Tablet
- Irritant (oropharyngeal)
Risedronate
Atelvia (US),
Actonel DR (Canada)
Tablet
- Modified-release
- Irritant (oropharyngeal)
Risperidone
Risperdal M
Tablet
- Must be allowed to dissolve on the tongue
Ritonavir
Norvir
Tablet
- Amorphous solid dispersion
Ropinirole
Requip XL (US)
Tablet
- Modified-release
Sirolimus
Rapamune
Tablet
- Nanocrystal
Solifenacin
Vesicare
Tablet
- Bad taste
Sulfasalazine
Azulfidine EN-Tabs (US),
Salazopyrin EN (Canada)
Tablet
- Modified-release
Suvorexant
Belsomra (US)
Tablet
- Amorphous solid dispersion
Tacrolimus
Astagraf XL (US)
Prograf
Capsule
- Amorphous solid dispersion
Tamsulosin
Flomax (US),
Flomax CR (Canada)
Capsule, Tablet
- Modified-release
Tapentadol
Nucynta ER
Tablet
- Modified-release
Temozolomide
Temodar (US),
Temodal (Canada)
Capsule
- Irritant (cytotoxic)
Tezacaftor/Ivacaftor
Symdeko
Tablet
- Amorphous solid dispersion
Theophylline
Theo-24 (US)
Capsule
- Modified-release
- Can be opened for administration of intact granules
Theophylline
Generics
Tablet
- Modified-release
Tipranavir
Aptivus
Capsule
- Bad taste
Tolterodine
Detrol LA
Capsule
- Modified-release
Topiramate
Topamax
Capsule, Tablet
- Bad taste
- Capsules can be opened for administration of intact granules
Topiramate
Qudexy XR (US),
Trokendi XR (US)
Capsule
- Modified-release
- Can be opened for administration of intact granules (Qudexy XR)
Tramadol
ConZip (US),
Ryzolt (US),
Ultram ER (US),
Zytram XL (Canada)
Capsule, Tablet
- Modified-release
Trazodone
Generics
Tablet
- Bad taste
- Scored tablets can be split
Trazodone
Oleptro
Tablet
- Modified-release
- Scored tablets can be split
Valganciclovir
Valcyte
Tablet
- Irritant
- Teratogenic, carcinogenic
Valproic Acid
Depakene
Capsule
- Irritant (oropharyngeal)
Vandetanib
Caprelsa
Tablet
- Antineoplastic
- Irritant
Vemurafenib
Zelboraf
Tablet
- Amorphous solid dispersion
Venetoclax
Venclexta
Tablet
- Amorphous solid dispersion
Venlafaxine
Effexor XR
Capsule
- Modified-release
- Can be opened for administration of intact granules
Verapamil
Verelan,
Verelan PM (US)
Capsule
- Modified-release
- Can be opened for administration of intact granules
Verapamil
Calan SR (US),
Covera-HS (US),
Isoptin SR
Tablet
- Modified-release
- Scored tablets can be split
Vismodegib
Erivedge
Capsule
- Teratogenic
Vorinostat
Zolinza
Capsule
- Irritant (skin and mucous membrane)
Zileuton
Zyflo CR (US)
Tablet
- Modified-release
Zolpidem
Ambien CR (US)
Tablet
- Modified-release
Zolpidem
Intermezzo (US)
Tablet
- Sublingual dosage form
